The potential of trace amines and their receptors for treating neurological and psychiatric diseases.

@article{Berry2007ThePO,
  title={The potential of trace amines and their receptors for treating neurological and psychiatric diseases.},
  author={Mark D. Berry},
  journal={Reviews on recent clinical trials},
  year={2007},
  volume={2 1},
  pages={
          3-19
        }
}
  • M. D. Berry
  • Published 2007
  • Biology
  • Reviews on recent clinical trials
Mining of the human genome has revealed approximately 7000 novel proteins, which could serve as potential targets for the development of novel therapeutics. Of these, approximately 2000 are predicted to be G-protein coupled receptors. Within this group of proteins, a family of 18 mammalian receptors has recently been identified that appear to exhibit selectivity toward the so-called trace amines. The trace amines are a family of endogenous compounds with strong structural similarity to… 

Tables from this paper

Trace Amines and Their Relevance to Psychiatry and Neurology: A Brief Overview
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There has been a resurgence of interest in these amines in the past decade with the discovery and cloning of a unique family of G-protein-coupled receptors, some of which are selectively activated by trace amines; these receptors have been termed trace amine, associated receptors (TAARs).
International Union of Pharmacology. LXXII. Recommendations for Trace Amine Receptor Nomenclature
TLDR
This review proposes an official nomenclature designating TAAR1 as the trace amine 1 receptor following the convention of naming receptors after the endogenous agonist, abbreviated to TA1 where necessary.
Human and mouse trace amine-associated receptor 1 have distinct pharmacology towards endogenous monoamines and imidazoline receptor ligands.
TLDR
The successful expression of human and mouse TAAR1 and the characterization of their responses to various natural and synthetic agonists raise new possibilities about the mechanism of some of the imidazoline-related agents.
Neuronal Functions and Emerging Pharmacology of TAAR1
TLDR
Brain and peripheral functions mediated by TAAR1 and other TAARs are reviewed, suggesting intriguing novelTAAR1 roles in system physiology.
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