The potential of the riboSNitch in personalized medicine

  title={The potential of the riboSNitch in personalized medicine},
  author={Amanda C Solem and Matthew Halvorsen and Silvia B V Ramos and Alain Laederach},
  booktitle={Wiley interdisciplinary reviews. RNA},
RNA conformation plays a significant role in stability, ligand binding, transcription, and translation. Single nucleotide variants (SNVs) have the potential to disrupt specific structural elements because RNA folds in a sequence-specific manner. A riboSNitch is an element of RNA structure with a specific function that is disrupted by an SNV or a single… CONTINUE READING