The potential of the mevalonate pathway for enhanced isoprenoid production.

  title={The potential of the mevalonate pathway for enhanced isoprenoid production.},
  author={Pan Liao and Andr{\'e}a Hemmerlin and Thomas J. Bach and Mee-Len Chye},
  journal={Biotechnology advances},
  volume={34 5},
The cytosol-localised mevalonic acid (MVA) pathway delivers the basic isoprene unit isopentenyl diphosphate (IPP). In higher plants, this central metabolic intermediate is also synthesised by the plastid-localised methylerythritol phosphate (MEP) pathway. Both MVA and MEP pathways conspire through exchange of intermediates and regulatory interactions. Products downstream of IPP such as phytosterols, carotenoids, vitamin E, artemisinin, tanshinone and paclitaxel demonstrate antioxidant… CONTINUE READING
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