The potential of restricted access media columns as applied in coupled-column LC/LC-TSP/MS/MS for the high-speed determination of target compounds in serum. Application to the direct trace analysis of salbutamol and clenbuterol.

@article{Hogendoorn1998ThePO,
  title={The potential of restricted access media columns as applied in coupled-column LC/LC-TSP/MS/MS for the high-speed determination of target compounds in serum. Application to the direct trace analysis of salbutamol and clenbuterol.},
  author={Elbert A. Hogendoorn and P van Zoonen and A Polettini and G Marrubini Bouland and Maria Cesarina Montagna},
  journal={Analytical chemistry},
  year={1998},
  volume={70 7},
  pages={1362-8}
}
This study investigated the potential of restricted access media (RAM) columns used as a first column in coupled-column LC hyphenated to thermospray tandem mass spectrometry (LC/LC-TSP/MS/MS) for the fast, selective, and sensitive determination of target drugs in serum samples. Because of their wide range in polarity, salbutamol and clenbuterol were chosen as model compounds and representatives of the class of beta 2-agonists. Three types of RAM columns were tested: (i) Pinkerton ISRP (internal… CONTINUE READING