The potential of mesenchymal stem cell in prion research.

  title={The potential of mesenchymal stem cell in prion research.},
  author={Diego R Mediano and David Sanz-Rubio and Beatriz Ranera and Rosa Bolea and Inmaculada Mart{\'i}n-Burriel},
  journal={Zoonoses and public health},
  volume={62 3},
Scrapie and bovine spongiform encephalopathy are fatal neurodegenerative diseases caused by the accumulation of a misfolded protein (PrP(res)), the pathological form of the cellular prion protein (PrP(C)). For the last decades, prion research has greatly progressed, but many questions need to be solved about prion replication mechanisms, cell toxicity, differences in genetic susceptibility, species barrier or the nature of prion strains. These studies can be developed in murine models of… CONTINUE READING