The potential of heparanase as a therapeutic target in cancer.

  title={The potential of heparanase as a therapeutic target in cancer.},
  author={Claudio C P Pisano and Israel Vlodavsky and Neta Ilan and Franco Zunino},
  journal={Biochemical pharmacology},
  volume={89 1},
Heparanase has generated substantial interest as therapeutic target for antitumor therapy, because its activity is implicated in malignant behavior of cancer cells and in tumor progression. Increased heparanase expression was found in numerous tumor types and correlates with poor prognosis. Heparanase, an endoglucuronidase responsible for heparan sulfate cleavage, regulates the structure and function of heparan sulfate proteoglycans, leading to disassembly of the extracellular matrix. The… CONTINUE READING
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