The potential of genes and other markers to inform about risk.

  title={The potential of genes and other markers to inform about risk.},
  author={Margaret Sullivan Pepe and Jessie Wen Gu and Daryl E. Morris},
  journal={Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology},
  volume={19 3},
BACKGROUND Advances in biotechnology have raised expectations that biomarkers, including genetic profiles, will yield information to accurately predict outcomes for individuals. However, results to date have been disappointing. In addition, statistical methods to quantify the predictive information in markers have not been standardized. METHODS We discuss statistical techniques to summarize predictive information, including risk distribution curves and measures derived from them, that relate… CONTINUE READING


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