The potential of cytokines as safety biomarkers for drug-induced liver injury

@article{Laverty2010ThePO,
  title={The potential of cytokines as safety biomarkers for drug-induced liver injury},
  author={Hugh G. Laverty and Daniel J Antoine and Craig Benson and Masautso Chaponda and Dominic P Williams and B. Kevin Park},
  journal={European Journal of Clinical Pharmacology},
  year={2010},
  volume={66},
  pages={961-976}
}
Drug-induced liver injury (DILI) is an event that has a detrimental impact on drug development and patient safety; therefore the identification of novel biomarkers that are both sensitive and specific to the liver would have great benefit. Inflammation is known to be associated with human cases of DILI, and given the role of cytokines in modulating the inflammatory response, changes in cytokine expression patterns certainly show promise as potential biomarkers of DILI. Cytokines are interesting… CONTINUE READING

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