The potential of antigen and TriMix sonoporation using mRNA-loaded microbubbles for ultrasound-triggered cancer immunotherapy.

@article{Dewitte2014ThePO,
  title={The potential of antigen and TriMix sonoporation using mRNA-loaded microbubbles for ultrasound-triggered cancer immunotherapy.},
  author={Heleen Dewitte and Sandra Van Lint and Carlo Heirman and Kris M. Thielemans and Stefaan C. De Smedt and Karine Breckpot and Ine Lentacker},
  journal={Journal of controlled release : official journal of the Controlled Release Society},
  year={2014},
  volume={194},
  pages={28-36}
}
Dendritic cell (DC)-based cancer vaccines, where the patient's own immune system is harnessed to target and destroy tumor tissue, have emerged as a potent therapeutic strategy. In the development of such DC vaccines, it is crucial to load the DCs with tumor antigens, and to simultaneously activate them to become more potent antigen-presenting cells. For this, we report on microbubbles, loaded with both antigen mRNA as well as immunomodulating TriMix mRNA, which can be used for the ultrasound… CONTINUE READING
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