The potential of Physcomitrella patens as a platform for the production of plant-based vaccines

@article{RosalesMendoza2014ThePO,
  title={The potential of Physcomitrella patens as a platform for the production of plant-based vaccines},
  author={Sergio Rosales-Mendoza and Luc{\'i}a Orellana-Escobedo and Andrea Romero-Maldonado and Eva L. Decker and Ralf Reski},
  journal={Expert Review of Vaccines},
  year={2014},
  volume={13},
  pages={203 - 212}
}
The moss Physcomitrella patens has a number of advantages for the production of biopharmaceuticals, including: i) availability of standardized conditions for cultivation in bioreactors; ii) not being part of the food chain; iii) high biosafety; iv) availability of highly efficient transformation methods; v) a haploid, fully sequenced genome providing genetic stability and uniform expression; vi) efficient gene targeting at the nuclear level allows for the generation of mutants with specific… 
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The first report on the recombinant production of a candidate vaccine in the moss system and opens the avenue for glycoengineering approaches for the production of HIV human-like glycosylated antigens as well as other vaccine prototypes under GMP conditions in moss bioreactors.
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