The potential of PDE4 inhibitors in asthma or COPD.

@article{Spina2000ThePO,
  title={The potential of PDE4 inhibitors in asthma or COPD.},
  author={Domenico Spina},
  journal={Current opinion in investigational drugs},
  year={2000},
  volume={1 2},
  pages={204-13}
}
  • Domenico Spina
  • Published 2000 in Current opinion in investigational drugs
At least 11 families of distinct phosphodiesterase (PDE) isoenzymes are known to regulate the function of many cells secondary to altering the intracellular levels of second messengers including cyclic 3'5-monophosphate (cyclic AMP) and cyclic 3'5 guanosine monophosphate (cyclic GMP). While there is a wide distribution of these enzymes throughout the body, it is of interest that inflammatory cells thought to participate in the pathogenesis of inflammatory diseases including asthma and chronic… CONTINUE READING

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