The potential of AOP networks for reproductive and developmental toxicity assay development.

@article{Knapen2015ThePO,
  title={The potential of AOP networks for reproductive and developmental toxicity assay development.},
  author={Dries Knapen and Lucia Vergauwen and Daniel L. Villeneuve and Gerald T. Ankley},
  journal={Reproductive toxicology},
  year={2015},
  volume={56},
  pages={52-5}
}
Historically, the prediction of reproductive and developmental toxicity has largely relied on the use of animals. The adverse outcome pathway (AOP) framework forms a basis for the development of new non-animal test methods. It also provides biological context for mechanistic information from existing assays. However, a single AOP may not capture all events that contribute to any relevant toxic effect, even in single chemical exposure scenarios. AOP networks, defined as sets of AOPs sharing at… CONTINUE READING

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A novel framework for interpretation of data from the fish short - term reproduction assay ( FSTRA ) for the detection OP networks for reproductive and developmental toxicity assay otox

  • GT Ankley, KM Jensen
  • Regul Toxicol Pharmacol

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