The potential impact of new generation transgenic methods on creating rabbit models of cardiac diseases.

@article{Bsze2016ThePI,
  title={The potential impact of new generation transgenic methods on creating rabbit models of cardiac diseases.},
  author={Zsuzsanna Bősze and P{\'e}ter Major and Istv{\'a}n Baczk{\'o} and Katja E. Odening and Lilla Bodrogi and L{\'a}szl{\'o} Hiripi and Andr{\'a}s Varr{\'o}},
  journal={Progress in biophysics and molecular biology},
  year={2016},
  volume={121 2},
  pages={
          123-30
        }
}
Since the creation of the first transgenic rabbit thirty years ago, pronuclear microinjection remained the single applied method and resulted in numerous important rabbit models of human diseases, including cardiac deficiencies, albeit with low efficiency. For additive transgenesis a novel transposon mediated method, e.g., the Sleeping Beauty transgenesis, increased the efficiency, and its application to create cardiac disease models is expected in the near future. The targeted genome… CONTINUE READING
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