The potential genotoxicity of sorbates: effects on cell cycle in vitro in V79 cells and somatic mutations in Drosophila.

@article{Schlatter1992ThePG,
  title={The potential genotoxicity of sorbates: effects on cell cycle in vitro in V79 cells and somatic mutations in Drosophila.},
  author={Josef Schlatter and Friedrich E. W{\"u}rgler and R Kr{\"a}nzlin and Peter Maier and E H Holliger and Ulrich Graf},
  journal={Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association},
  year={1992},
  volume={30 10},
  pages={843-51}
}
Sodium sorbate, potassium sorbate and an oxidation product of sodium sorbate, 4,5-epoxy-2-hexenoic acid, were tested for their genotoxic potential in cultured V79 Chinese hamster cells and in somatic cells of Drosophila melanogaster (wing spot test, SMART). In Drosophila only the epoxide showed a weak genotoxic effect. In V79 cells, freshly prepared sodium sorbate solutions at the highest concentrations only (2.5 mg/ml, 24 hr exposure) arrested mitosis at the G2/M cell cycle phase and potassium… CONTINUE READING

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