The potential benefits of creatine and conjugated linoleic acid as adjuncts to resistance training in older adults.

@article{Tarnopolsky2008ThePB,
  title={The potential benefits of creatine and conjugated linoleic acid as adjuncts to resistance training in older adults.},
  author={Mark Andrew Tarnopolsky and Adeel Safdar},
  journal={Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme},
  year={2008},
  volume={33 1},
  pages={
          213-27
        }
}
  • M. TarnopolskyA. Safdar
  • Published 8 January 2008
  • Biology
  • Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme
Human aging is associated with a significant reduction in muscle mass (sarcopenia) resulting in muscle weakness and functional limitations in the elderly. Sarcopenia has been associated with mitochondrial dysfunction and the accumulation of mtDNA deletions. Resistance training increases muscle strength and size and can increase mitochondrial capacity and decrease oxidative stress in older adults. Creatine monohydrate (CrM) and conjugated linoleic acid (CLA) have biological effects that could… 

Exercise and nutritional interventions for improving aging muscle health

Additional research is needed to determine whether skeletal muscle adaptations to increased activity in older adults are further enhanced with effective nutritional interventions and whether this is due to enhanced muscle protein synthesis, improved mitochondrial function, and/or a reduced inflammatory response.

Creatine Supplementation in the Elderly: is Resistance Training Really Needed?

There is good evidence to suggest that creatine supplementation with resistance training increases muscular endurance, lower body strength and lean body mass; this is above results obtained with creatine supplementation or resistance training alone.

Advantages of dietary, exercise-related, and therapeutic interventions to prevent and treat sarcopenia in adult patients: an update

The aim of this review is to provide an update on the current knowledge of the definition, etiology, consequences, and current clinical trials that may help address this pressing public health problem for aging populations.

Mitochondrial DNA shifting in older adults following resistance exercise training.

  • M. Tarnopolsky
  • Education, Biology
    Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme
  • 2009
Preliminary data strongly suggest that mitochondrial DNA shifting occurs in skeletal muscle from older adults following resistance-exercise training.

A Five-Ingredient Nutritional Supplement and Home-Based Resistance Exercise Improve Lean Mass and Strength in Free-Living Elderly

It is concluded that the Muscle5 supplement is a safe, well-tolerated, and effective complement to low-intensity, home-based resistance exercise and improves lean mass, strength, and overall muscle quality in old age.

Creatine supplementation and aging musculoskeletal health

Meta-analyses indicate creatine supplementation combined with resistance training has a positive effect on aging muscle mass and upper body strength compared to resistance training alone and Creatine also shows promise for improving bone mineral density and indices of bone biology.

Aberrant Mitochondrial Homeostasis in the Skeletal Muscle of Sedentary Older Adults

It is proposed that an active lifestyle is an important determinant of quality of life and molecular progression of aging in skeletal muscle of the elderly, and is a viable therapy for attenuating and/or reversing skeletal muscle strength declines and mitochondrial abnormalities associated with aging.

Role of creatine supplementation on exercise-induced cardiovascular function and oxidative stress

It is suggested that short-term creatine supplementation does not enhance non-enzymatic antioxidant defence or protect against lipid peroxidation induced by exhaustive cycling in healthy males.

Efficacy of Nutritional Interventions as Stand-Alone or Synergistic Treatments with Exercise for the Management of Sarcopenia

The purpose of this review is to provide an overview on the role of proteins and other key nutrients, alone or in combination with physical exercise, on muscle parameters.

References

SHOWING 1-10 OF 135 REFERENCES

Creatine Monohydrate and Conjugated Linoleic Acid Improve Strength and Body Composition Following Resistance Exercise in Older Adults

Data confirms that supervised resistance exercise training is safe and effective for increasing strength in older adults and that a combination of CrM and CLA can enhance some of the beneficial effects of training over a six-month period.

Effects of Conjugated Linoleic Acid Supplementation During Resistance Training on Body Composition, Bone Density, Strength, and Selected Hematological Markers

Findings indicate that CLA does not appear to possess significant ergogenic value for experienced resistance-trained athletes and general markers of catabolism and immunity during training are not affected.

Mitochondrial DNA shifting in older adults following resistance exercise training.

  • M. Tarnopolsky
  • Education, Biology
    Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme
  • 2009
Preliminary data strongly suggest that mitochondrial DNA shifting occurs in skeletal muscle from older adults following resistance-exercise training.

The effects of conjugated linoleic acid supplementation during resistance training.

PURPOSE We determined the effects of conjugated linoleic acid (CLA) supplementation during resistance training. METHODS Seventy-six subjects were randomized to receive CLA (5 g.d(-1)) or placebo

Creatine monohydrate and resistance training increase bone mineral content and density in older men.

Resistance training of 12 weeks increases bone mineral density in older men and creatine supplementation may provide an additional benefit for increasing regional bone mineral content, due to an enhanced muscle mass with creatine.

Effects of resistance training and chromium picolinate on body composition and skeletal muscle in older men.

High-dose CrPic supplementation did not enhance muscle size, strength, or power development or lean body mass accretion in older men during a RT program, which had significant, independent effects on these measurements.

Long-term creatine intake is beneficial to muscle performance during resistance training.

It is concluded that long-term creatine supplementation enhances the progress of muscle strength during resistance training in sedentary females.

Nutritional therapy improves function and complements corticosteroid intervention in mdx mice

Evidence for therapeutic benefit from a four‐compound combination therapy alone, in combination, and in conjunction with corticosteroids in the mdx model of DMD is provided.

Beneficial effects of creatine supplementation in dystrophic patients

Cr may provide some symptomatic benefit in these patients with Duchenne muscular dystrophy, and urinary excretion of collagen type I cross‐linking N‐telopeptide declined to about one third after Cr, and no adverse effect was observed.
...