The potent cell permeable calpain inhibitor MDL28170 affects the interaction of Leishmania amazonensis with macrophages and shows anti-amastigote activity.

Abstract

Since the discovery of the28 first drugs used in leishmaniasis treatment up to now, the search for compounds with anti-Leishmania activity without toxic effects and able to overcome the emergency of resistant strains remains a major goal to combat this neglected disease. With this in mind, in the present work, we evaluated the effects of the calpain… (More)
DOI: 10.1016/j.parint.2017.06.010

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Cite this paper

@article{Marinho2017ThePC, title={The potent cell permeable calpain inhibitor MDL28170 affects the interaction of Leishmania amazonensis with macrophages and shows anti-amastigote activity.}, author={Fernanda de Aquino Marinho and Leandro Stefano Sangenito and Simone S. C. Oliveira and Luciana B. de Arruda and Cl{\'a}udia Masini d'Avila-Levy and Andr{\'e} Luis Souza dos Santos and Marta Helena Branquinha}, journal={Parasitology international}, year={2017}, volume={66 5}, pages={579-583} }