The potassium channel modulator flupirtine shifts the frequency–response function of hippocampal synapses to favour LTD in mice

@article{Azad2004ThePC,
  title={The potassium channel modulator flupirtine shifts the frequency–response function of hippocampal synapses to favour LTD in mice},
  author={Shahnaz Christina Azad and Matthias Eder and Wanda Simon and Gerhard Hapfelmeier and Hans-Ulrich Dodt and Walter Zieglgänsberger and Gerhard Rammes},
  journal={Neuroscience Letters},
  year={2004},
  volume={370},
  pages={186-190}
}
The Kv7 potassium channel activator flupirtine affects clinical excitability parameters of myelinated axons in isolated rat sural nerve
TLDR
Assessment of measures of excitability that are altered in the myelinated axons of patients with peripheral nerve disorders indicates that neuropathies with abnormal nerve excitability parameters corresponding to those affected by flupirtine may benefit from activation of axonal Kv7 potassium channels.
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A global model was developed in which flupirtine stabilizes the resting membrane potential by activating inwardly rectifying K+ channels, thus indirectly inhibiting the activation of NMDA receptors.
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Results show that in cultured hippocampal neurones flupirtine activates an inwardly rectifying potassium current and that a PTX‐sensitive G‐protein is involved in the transduction mechanism.
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