The potassium channel KCa3.1 constitutes a pharmacological target for neuroinflammation associated with ischemia/reperfusion stroke.

@article{Chen2016ThePC,
  title={The potassium channel KCa3.1 constitutes a pharmacological target for neuroinflammation associated with ischemia/reperfusion stroke.},
  author={Yi-Je Chen and Hai M. Nguyen and Izumi Maezawa and Eva Melanie Gr{\"o}ssinger and April Lourdes A Garing and Ralf K{\"o}hler and Lee-way Jin and Heike Wulff},
  journal={Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism},
  year={2016},
  volume={36 12},
  pages={
          2146-2161
        }
}
Activated microglia/macrophages significantly contribute to the secondary inflammatory damage in ischemic stroke. Cultured neonatal microglia express the K+ channels Kv1.3 and KCa3.1, both of which have been reported to be involved in microglia-mediated neuronal killing, oxidative burst and cytokine production. However, it is questionable whether neonatal cultures accurately reflect the K+ channel expression of activated microglia in the adult brain. We here subjected mice to middle cerebral… CONTINUE READING

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