The postsynaptic density: a possible role in long-lasting effects in the central nervous system.

@article{Siekevitz1985ThePD,
  title={The postsynaptic density: a possible role in long-lasting effects in the central nervous system.},
  author={Philip Siekevitz},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1985},
  volume={82 10},
  pages={3494-8}
}
  • Philip Siekevitz
  • Published 1985 in
    Proceedings of the National Academy of Sciences…
A theory is proposed that biochemical changes at the synapse that occur as a result of stimulation of specific neuronal circuits can lead to long-term changes only if alterations occur in synaptic structures in these circuits. The main synaptic structure that is thought to undergo this alteration is the postsynaptic density (PSD). There are many reports in the literature of overall structural changes at the synapse, including the PSD, resulting from various neuronal stimuli. These structural… CONTINUE READING

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