The post illumination pupil response is reduced in seasonal affective disorder

@article{Roecklein2013ThePI,
  title={The post illumination pupil response is reduced in seasonal affective disorder},
  author={Kathryn A. Roecklein and Patricia May Ling. Wong and Natalie C. Ernecoff and Megan A. Miller and Peter Franz{\'e}n},
  journal={Psychiatry Research},
  year={2013},
  volume={210},
  pages={150-158}
}
Individuals with seasonal affective disorder (SAD) may have a decreased retinal sensitivity in the non-image forming light-input pathway. We examined the post illumination pupil response (PIPR) among individuals with SAD and healthy controls to identify possible differences in the melanopsin signaling pathway. We also investigated whether melanopsin gene (OPN4) variations would predict variability in the PIPR. Fifteen SAD and 15 control participants (80% women, mean age 36.7 years, S.D.=14.5… CONTINUE READING
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