The post-antibiotic era is here

  title={The post-antibiotic era is here},
  author={Jennie H. Kwon and William G. Powderly},
  pages={471 - 471}
Imagine a world where routine surgery or chemotherapy is considered too dangerous because there are no drugs to prevent or treat bacterial infections. Unless researchers develop new antibiotics and therapeutics, the decimation of modern medicine will soon become a reality. Scientists have long recognized that much stronger incentives for research and development are needed to avoid this scenario. Yet, the rise of “superbugs” has continued, making a pandemic of antibiotic resistance a major… 

Will the mRNA vaccine platform be the panacea for the development of vaccines against antimicrobial resistant (AMR) pathogens?

New and distinct classes of antimicrobials are urgently needed to develop for patients infected with AMR pathogens, and innovative approaches are needed for the development of vaccines as an alternative to combat AMR.

Revisiting Antibiotic Resistance: Mechanistic Foundations to Evolutionary Outlook

The key molecular mechanisms of resistance development in clinical settings and their spontaneous evolution are discussed and prediction of possible evolutionary lineages of resistant bacteria could offer an unswerving impact in precision medicine.

Impact of coronavirus disease 2019 (COVID-19) pandemic on antimicrobial consumption and antimicrobial resistance at a small, local hospital in Japan

The impact of COVID-19 on antimicrobial stewardship at a small, local hospital in Japan is discussed and antibiotic stewardship needs to continue regardless of hospital size or supervening crises.

Clinical trials with antiviral drugs against COVID‐19: some progress and many shattered hopes

Large pragmatic clinical trials particularly of the British RECOVERY trial series demonstrated that even under emergency situation drug trials can be conducted in a timely way such that the therapy of COVID‐19 patients can be based on evidence basis instead on expert opinion or even worse on political pressure.

Non-viral infections and antimicrobial resistance in the time of COVID-19: what to expect?

Given the scale of the pandemic, overuse and misuse of antibiotics and antifungals can increase resistance rates and emergence of multidrug resistant (MDR) bacteria and fungi.

Antibacterial effects of vanilla ingredients provide novel treatment options for infections with multidrug-resistant bacteria – A recent literature review

Vanillin and vanillic acid constitute promising alternative or adjunct options in the combat of infections caused by MDR bacterial pathogens, and pronounced synergistic effects directed against distinct pathogenic including ESCAPE strains could be observed.

Recent Advances in the Development of Lipid-, Metal-, Carbon-, and Polymer-Based Nanomaterials for Antibacterial Applications

This review covers the latest advances of nanotechnologies used in the design and development of nano- and nanocomposite materials to fight MDR bacteria with different purposes.


  • Fadhila Diah Suminar
  • Medicine
  • 2022
There are irrational antibiotic prescriptions and Ceftriaxone became the most commonly prescribed antibiotic in Indonesia in the period July to December 2021.

The Search for Antibacterial Inhibitors Targeting Cell Division Protein FtsZ at Its Nucleotide and Allosteric Binding Sites

This work focuses on methods to characterize synthetic inhibitors that either replace bound GTP from the FtsZ nucleotide binding pocket conserved across diverse bacteria or selectively bind into the allosteric site at the interdomain cleft of Fts Z from Bacillus subtilis and the pathogen Staphylococcus aureus.