The possible role of tissue-type plasminogen activator and the plasminogen system in the pathogenesis of major depression.

@article{Tsai2006ThePR,
  title={The possible role of tissue-type plasminogen activator and the plasminogen system in the pathogenesis of major depression.},
  author={Shih-Jen Tsai},
  journal={Medical hypotheses},
  year={2006},
  volume={66 2},
  pages={319-22}
}
Major depressive disorder (MDD) is one of the most common psychiatric illnesses with an unknown etiology. Evidence from animal and human studies has suggested that brain-derived neurotrophic factor (BDNF) function may be implicated in the pathogenesis of MDD. Tissue-type plasminogen activator (tPA) is a highly specific serine proteinase that catalyses the generation of zymogen plasminogen from the proteinase plasmin. Recent studies have found that the proteolytic cleavage of proBDNF, a BDNF… CONTINUE READING
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