The possible role of matrix metalloproteinase (MMP)-2 and MMP-9 in cancer, e.g. acute leukemia.

@article{Klein2004ThePR,
  title={The possible role of matrix metalloproteinase (MMP)-2 and MMP-9 in cancer, e.g. acute leukemia.},
  author={Gerd Klein and Edo Vellenga and Marco W Fraaije and Willem A. Kamps and Eveline S. J. M. de Bont},
  journal={Critical reviews in oncology/hematology},
  year={2004},
  volume={50 2},
  pages={87-100}
}
In the past decades, a lot of effort has been put in identifying the role of matrix metalloproteinases (MMPs) in cancer. The main role of MMPs in angiogenesis, tumor growth and metastasis is degradation of extracellular matrix (ECM) and release and/or activation of growth factors through their degradative activity. The degradative activity finally results in cancer progression. MMP-inhibitors (MMPIs) have already been designed and tested, based on the degradative role of MMPs in cancer… CONTINUE READING

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