The possible role of hepatitis A virus in the pathogenesis of atherosclerosis.

  title={The possible role of hepatitis A virus in the pathogenesis of atherosclerosis.},
  author={Jianhui Zhu and Arshed A Quyyumi and James E Norman and Rene Costello and Gyorgy Csako and Stephen E. Epstein},
  journal={The Journal of infectious diseases},
  volume={182 6},
The possible association between hepatitis A virus (HAV) infection and coronary artery disease (CAD) was studied. Blood from 391 patients undergoing coronary angiography was tested for serum IgG antibodies to HAV and C-reactive protein (CRP). Of the 391 patients, 205 (52%) had anti-HAV IgG antibodies. CAD prevalence was 74% in HAV-seropositive and 52% in HAV-seronegative patients (P<.0001); significance persisted after adjustment for either traditional CAD risk factors or for risk factors plus… CONTINUE READING

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