The possible role of cross-reactive dengue virus antibodies in Zika virus pathogenesis

@inproceedings{Langerak2019ThePR,
  title={The possible role of cross-reactive dengue virus antibodies in Zika virus pathogenesis},
  author={Thomas Langerak and Noreen Mumtaz and Vera I Tolk and Eric C M van Gorp and Byron E. E. Martina and Barry Rockx and Marion P G Koopmans},
  booktitle={PLoS pathogens},
  year={2019}
}
Zika virus (ZIKV) has been known for decades to circulate in Africa and Asia. However, major complications of a ZIKV infection have recently become apparent for reasons that are still not fully elucidated. One of the hypotheses for the seemingly increased pathogenicity of ZIKV is that cross-reactive dengue antibodies can enhance a ZIKV infection through the principle of antibody-dependent enhancement (ADE). Recently, ADE in ZIKV infection has been studied, but conclusive evidence for the… CONTINUE READING
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