The possible role of autoimmunity in the pathogenesis of diabetes in B-thalassemia major.

@article{Monge2001ThePR,
  title={The possible role of autoimmunity in the pathogenesis of diabetes in B-thalassemia major.},
  author={Luca Monge and Silvia Pinach and Lucia Caramellino and Maria Tiziana Bertero and A Dall'omo and Quirico Carta},
  journal={Diabetes & metabolism},
  year={2001},
  volume={27 2 Pt 1},
  pages={149-54}
}
OBJECTIVE To evaluate the possible role of autoimmunity in the pathogenesis of diabetes associated with B-thalassemia, we studied a cohort of 53 B-thalassemic individuals, under long term blood transfusion, that included twelve patients with diabetes (22.6%). MATERIAL AND METHODS To evaluate the activation of an autoimmune response, individuals were tested for islet cell antibodies (ICA), glutamic acid decarboxylase (GAD) autoantibodies, insulin autoantibodies (IAA) and serum anti-nuclear… CONTINUE READING