The possible mode of action of prostaglandins: XVI. A study to assess the local effect of prostaglandins E1, E2 or F2 alpha in the regulation of male fertility.


A single intratesticular injection of prostaglandin E1 (PGE1) or prostaglandin E2 (PGE2) at a dose of 2.5 mg/kg was found to interfere with the fertilizing ability of epididymal spermatozoa of the test animals both in the injected and contralateral control sides. Prostaglandin F2 alpha, conversely, was found to be ineffective in terms of fertility of the… (More)


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