The possible implication of trans-Resveratrol in the cardioprotective effects of long-term moderate wine consumption.

  title={The possible implication of trans-Resveratrol in the cardioprotective effects of long-term moderate wine consumption.},
  author={Francisco Orallo and Ezequiel {\'A}lvarez and Mercedes Cami{\~n}a and Jos{\'e} Manuel Leiro and E. Alcocer G{\'o}mez and P Fernandez},
  journal={Molecular pharmacology},
  volume={61 2},
trans-Resveratrol (t-RESV; 1-10 microM), a phenolic component of wines, had no effect on phenylephrine-(PE; 1 microM) and high KCl-(60 mM) induced contractions in endothelium-denuded rat aortic rings. However, it relaxed the contractile response produced by these vasoconstrictor agents in intact rat aorta. The vasorelaxing effects of t-RESV were completely inhibited by N(G)-nitro-L-arginine (L-NOARG; 0.1 mM) and methylene blue (10 microM), but they were unaffected by atropine (10 microM) and… 

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