The possibility of neurotoxicity in the hippocampus in major depression: a primer on neuron death.

@article{Sapolsky2000ThePO,
  title={The possibility of neurotoxicity in the hippocampus in major depression: a primer on neuron death.},
  author={Robert Morris Sapolsky},
  journal={Biological psychiatry},
  year={2000},
  volume={48 8},
  pages={755-65}
}
A number of studies indicate that prolonged, major depression is associated with a selective loss of hippocampal volume that persists long after the depression has resolved. This review is prompted by two ideas. The first is that overt neuron loss may be a contributing factor to the decrease in hippocampal volume. As such, the first half of this article reviews current knowledge about how hippocampal neurons die during insults, focusing on issues related to the trafficking of glutamate and… CONTINUE READING
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Gene therapy for acute neurological insults.Neurology10:1922–1931

  • R Sapolsky, G Steinberg
  • 1999
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