The positive inotropic effect of endothelin-1 is mediated by mitochondrial reactive oxygen species.

@article{Giusti2008ThePI,
  title={The positive inotropic effect of endothelin-1 is mediated by mitochondrial reactive oxygen species.},
  author={Ver{\'o}nica Celeste De Giusti and Mar{\'i}a V. Correa and Mar{\'i}a Celeste Villa-Abrille and C Beltrano and Alejandra M Yeves and Gladys E Chiappe de Cingolani and Horacio Eugenio Cingolani and Ernesto Alejandro Aiello},
  journal={Life sciences},
  year={2008},
  volume={83 7-8},
  pages={264-71}
}
We have previously demonstrated the participation of reactive oxygen species (ROS) in the positive inotropic effect of a physiological concentration of Angiotensin II (Ang II, 1 nM). The objective of the present work was to evaluate the role and source of ROS generation in the positive inotropic effect produced by an equipotent concentration of endothelin-1 (ET-1, 0.4 nM). Isolated cat ventricular myocytes were used to measure sarcomere shortening with a video-camera, superoxide anion (()O(2… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 27 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 63 references

cells from the diabetic rat

  • A. K. Snabaitis, D. J. Hearse, M. Avkiran
  • Journal of Physiology
  • 2002
Highly Influential
6 Excerpts

Similar Papers

Loading similar papers…