The positive effect of Botulinum toxin type A on the viability of random flap in tobacco exposed in rats.

Abstract

PURPOSE: To evaluate the effect of Botulinum Toxin A in different time of tobacco exposure. METHODS: 60 male, Wistar rats were divided into two tobacco exposure groups: a 2- month or a 4-month regimen. After this period, these two groups were subdivided as two: saline solution(SS) or botulinum toxin A(Bonta), at the time of the surgery. Seven days before the SS or Bonta injection, the animals were submitted to a random flap (3x10cm). On the seventh postoperative day, all animals were assessed for total flap area, viable area, and the viable/ total area ratio. RESULTS: This study showed a difference between groups 2-month saline vs. BontA injection (p=0.04); groups 4-month saline vs. BontA injection (p=0.001); groups 2-month saline vs. 4-month BontA (p=0.003), and, between groups 2- month BontA vs. 4-month saline(p=0.03). CONCLUSIONS: Botulinum Toxin A increased random flap viability in tobacco-exposed rats. Two months of tobacco exposure had the same effect as exposure for four months.

DOI: 10.1590/S0102-865020160110000003

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Cite this paper

@article{Camargo2016ThePE, title={The positive effect of Botulinum toxin type A on the viability of random flap in tobacco exposed in rats.}, author={Cristina Pires Camargo and Felipe Alexandre Fernandes and Michel Hyo Mi Lee and Luiza Campos Moreira Silva and J{\'u}lio Morais Besteiro and Rolf Gemperli}, journal={Acta cirurgica brasileira}, year={2016}, volume={31 11}, pages={720-723} }