The positional influence of the helical geometry of the heteroduplex substrate on human RNase H1 catalysis.

Abstract

In a companion study published in this issue (p. 83), we showed that chimeric substrates containing 2'-methoxyethyl (MOE) nucleotides inhibited human RNase H1 activity. In this study, we prepared chimeric substrates containing a central DNA region with flanking northern-biased MOE nucleotides hybridized to complementary RNA. Conformationally biased and… (More)

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@article{Lima2007ThePI, title={The positional influence of the helical geometry of the heteroduplex substrate on human RNase H1 catalysis.}, author={Walt F. Lima and John B. Rose and Josh G. Nichols and Hongjiang Wu and Michael T. Migawa and T. K. Wyrzykiewicz and Guillermo Leopoldo Kemper Vasquez and Eric E. Swayze and Stanley T. Crooke}, journal={Molecular pharmacology}, year={2007}, volume={71 1}, pages={73-82} }