The position of phosphorylcholine on the lipopolysaccharide of Haemophilus influenzae affects binding and sensitivity to C-reactive protein-mediated killing.

@article{Lysenko2000ThePO,
  title={The position of phosphorylcholine on the lipopolysaccharide of Haemophilus influenzae affects binding and sensitivity to C-reactive protein-mediated killing.},
  author={Elena S. Lysenko and James C. Richards and Andrew D Cox and Aengus Stewart and Ad{\`e}le Martin and Mili Kapoor and Jeffrey N Weiser},
  journal={Molecular microbiology},
  year={2000},
  volume={35 1},
  pages={234-45}
}
The lic1 locus of Haemophilus influenzae controls the incorporation of environmental choline into lipopolysaccharide (LPS) as phosphorylcholine (ChoP) as well as the phase variation of this structure. ChoP is the target of an acute phase reactant in serum, C-reactive protein (CRP), which mediates killing through the activation of complement when bound to the organism. Structural analysis of the oligosaccharide region of the H. influenzae LPS showed that ChoP is linked to different hexose… CONTINUE READING

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