OBJECTIVE To evaluate influence of hormonal contraceptive drospirenone on premenstrual syndrome (PMS). DESIGN Overall summary of literature. AUTHOR AFFILIATION: ADC Sanatorium, Praha. METHODS Review of scientific studies and publications. CONCLUSIONS The author submitted current opinions on premenstrual syndrome, its classification, and treatment. The role of renin--aldosterone system in the genesis of PMS was described. Basic pharmacological characteristics of the remedy containing in one pill 30 mg of Ethinyl Estradiol (EE) and 3 mg of drospirenone are presented. Its therapeutic effects on somatic and psychological PMS symptoms are discussed.