The porin and the permeating antibiotic: a selective diffusion barrier in Gram-negative bacteria

  title={The porin and the permeating antibiotic: a selective diffusion barrier in Gram-negative bacteria},
  author={Jean-Marie Pag{\'e}s and Chloe E. James and Mathias Winterhalter},
  journal={Nature Reviews Microbiology},
Gram-negative bacteria are responsible for a large proportion of antibiotic-resistant bacterial diseases. These bacteria have a complex cell envelope that comprises an outer membrane and an inner membrane that delimit the periplasm. The outer membrane contains various protein channels, called porins, which are involved in the influx of various compounds, including several classes of antibiotics. Bacterial adaptation to reduce influx through porins is an increasing problem worldwide that… 

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  • H. Nikaido
  • Biology
    Microbiology and Molecular Biology Reviews
  • 2003
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