The porcine lung as a potential model for cystic fibrosis.

@article{Rogers2008ThePL,
  title={The porcine lung as a potential model for cystic fibrosis.},
  author={Christopher S. Rogers and William M. Abraham and Kim A. Brogden and John F. Engelhardt and John Timothy Fisher and Paul B. McCray and Geoffrey McLennan and David K. Meyerholz and Eman Namati and Lynda S. Ostedgaard and Randall S Prather and Juan R Sabater and David A. Stoltz and Joseph Zabner and Michael J. Welsh},
  journal={American journal of physiology. Lung cellular and molecular physiology},
  year={2008},
  volume={295 2},
  pages={L240-63}
}
Airway disease currently causes most of the morbidity and mortality in patients with cystic fibrosis (CF). However, understanding the pathogenesis of CF lung disease and developing novel therapeutic strategies have been hampered by the limitations of current models. Although the gene encoding the cystic fibrosis transmembrane conductance regulator (CFTR) has been targeted in mice, CF mice fail to develop lung or pancreatic disease like that in humans. In many respects, the anatomy, biochemistry… CONTINUE READING

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Cystic fibrosis. In: The Metabolic and Molecular Basis of Inherited Disease (8th ed.), edited

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