The population dynamics of antimicrobial chemotherapy.

@article{Lipsitch1997ThePD,
  title={The population dynamics of antimicrobial chemotherapy.},
  author={Marc Lipsitch and Bruce R. Levin},
  journal={Antimicrobial agents and chemotherapy},
  year={1997},
  volume={41 2},
  pages={363-73}
}
We present and analyze a series of mathematical models for the emergence of resistance during antibiotic treatment of an infected host. The models consider the population dynamics of antibiotic-sensitive and -resistant bacteria during the course of treatment and addresses the following problems: (i) the probability of obtaining a resistant mutant during the course of treatment as a function of antibiotic exposure; (ii) the conditions under which high, infrequent doses of an antibiotic are… CONTINUE READING