The polysulphated polyxylan Hoe/Bay-946 inhibits HIV replication on human monocytes/macrophages.

  title={The polysulphated polyxylan Hoe/Bay-946 inhibits HIV replication on human monocytes/macrophages.},
  author={H. von Briesen and C. Meichsner and R. Andreesen and R. Esser and E. Schrinner and H. Rübsamen-Waigmann},
  journal={Research in virology},
  volume={141 2},
  • H. von Briesen, C. Meichsner, +3 authors H. Rübsamen-Waigmann
  • Published 1990
  • Biology, Medicine
  • Research in virology
  • Due to the important role of monocytes/macrophages in the pathogenesis of AIDS, potential drugs with anti-HIV activity in lymphocytes must also be effective in monocytes/macrophages. For testing the efficacy of antiviral substances, monocytes/macrophages from peripheral blood were infected, respectively, with highly replicating HIV1 and HIV2 strains, thereby providing an extremely sensitive system of testing. Azidothymidine was found to inhibit both HIV types at 0.04 microgram/ml. The… CONTINUE READING
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