The polysaccharide fraction of Propionibacterium acnes modulates the development of experimental focal segmental glomerulosclerosis.

@article{Reis2012ThePF,
  title={The polysaccharide fraction of Propionibacterium acnes modulates the development of experimental focal segmental glomerulosclerosis.},
  author={Vanessa Oliveira Reis and Janice Costa Silva and Gabriela Trindade Souza and Patr{\'i}cia Semedo and Bruna N. Buscariollo and Rafael Luiz Pereira and Marcos Ant{\^o}nio Cenedeze and {\'A}lvaro Pacheco-Silva and Ieda M Longo-Maug{\'e}ri and Niels Olsen Saraiva C{\^a}mara and Alexandre Castro Keller},
  journal={Immunobiology},
  year={2012},
  volume={217 9},
  pages={
          831-41
        }
}
The pathogenesis of focal segmental glomerulosclerosis (FSGS) appears to be associated with type-2 cytokines and podocyte dysfunction. In this study, we tested the hypothesis that immunization with the polysaccharide fraction of Propionibacterium acnes (PS), a pro-Th1 agonist, may subvert the type-2 profile and protect podocytes from adriamycin-induced glomerulosclerosis. Adriamycin injection resulted in albuminuria and increased serum creatinine in association with loss of glomerular podocin… CONTINUE READING
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