The polypyrimidine tract binding protein is required for efficient picornavirus gene expression and propagation.

@article{Florez2005ThePT,
  title={The polypyrimidine tract binding protein is required for efficient picornavirus gene expression and propagation.},
  author={Paola M Florez and October Michael Sessions and Eric J. Wagner and Matthias Gromeier and Mariano A. Garcia-Blanco},
  journal={Journal of virology},
  year={2005},
  volume={79 10},
  pages={6172-9}
}
Mammalian host factors required for efficient viral gene expression and propagation have been often recalcitrant to genetic analysis. A case in point is the function of cellular factors that trans-activate internal ribosomal entry site (IRES)-driven translation, which is operative in many positive-stranded RNA viruses, including all picornaviruses. These IRES trans-acting factors have been elegantly studied in vitro, but their in vivo importance for viral gene expression and propagation has not… CONTINUE READING