The polypyrimidine tract-binding protein is required for efficient dengue virus propagation and associates with the viral replication machinery.

@article{Anwar2009ThePT,
  title={The polypyrimidine tract-binding protein is required for efficient dengue virus propagation and associates with the viral replication machinery.},
  author={Azlinda Anwar and Kok Mun Leong and Mary Mah-Lee Ng and Justin Jang-hann Chu and Mariano A. Garcia-Blanco},
  journal={The Journal of biological chemistry},
  year={2009},
  volume={284 25},
  pages={17021-9}
}
The polypyrimidine tract-binding protein (PTB) functions primarily as an IRES trans-acting factor in the propagation of hepatitis C virus and picornaviruses. PTB interacts with secondary structures within the 3'- and 5'-untranslated regions of these viral genomes to mediate efficient IRES-mediated viral translation. PTB has also been reported to bind to the untranslated region of the single-stranded RNA dengue virus (DENV), suggesting a similar function for PTB in flaviviruses. Indeed small… CONTINUE READING
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