The polyol pathway, sorbinil, and renal dysfunction.

  • A Beyer-Mears
  • Published 1986 in Metabolism: clinical and experimental


Nephropathy is a serious complication of Type I or insulin-dependent diabetes mellitus (IDDM) with a poor prognosis after the onset of proteinuria. Since aldose reductase may be implicated in the pathogenesis of proteinuria, onset and reversal studies were performed with sorbinil at a dose of 20 mg/kg to determine whether inhibition of this enzyme promoted… (More)


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