The polymorphisms of UCP1 genes associated with fat metabolism, obesity and diabetes

@article{Jia2009ThePO,
  title={The polymorphisms of UCP1 genes associated with fat metabolism, obesity and diabetes},
  author={Jun-jing Jia and Yun-bo Tian and Zhen-hui Cao and Lin-li Tao and Xi Zhang and Si-zhen Gao and Chang-rong Ge and Qiu-Ye Lin and Markandeya Jois},
  journal={Molecular Biology Reports},
  year={2009},
  volume={37},
  pages={1513-1522}
}
Uncoupling protein 1 (UCP1), a 32-kDa protein located in the inner mitochondrial membrane, is abundant in brown adipose tissue, as a proton transporter in mitochondria inner membrane which uncouples oxidative metabolism from ATP synthesis and dissipates energy through the heat. UCP1 has been reported to play important roles for energy homeostasis in rodents and neonate of larger mammals including human. Recently, numerous candidate genes were searched to determine the genetic factors implicated… CONTINUE READING
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