The polymorphisms of P53 codon 72 and MDM2 SNP309 and renal cell carcinoma risk in a low arsenic exposure area.

@article{Huang2011ThePO,
  title={The polymorphisms of P53 codon 72 and MDM2 SNP309 and renal cell carcinoma risk in a low arsenic exposure area.},
  author={Chao-yuan Huang and Chien-Tien Su and J. Chu and Shu-Pin Huang and Y K Pu and Hsiu-Yuan Yang and Chi-Jung Chung and Chia-Chang Wu and Y L Hsueh},
  journal={Toxicology and applied pharmacology},
  year={2011},
  volume={257 3},
  pages={349-55}
}
Our recent study demonstrated the increased risk of renal cell carcinoma (RCC) associated with high urinary total arsenic levels among people living in a low arsenic exposure area. Genomic instability is important in arsenic carcinogenesis. This study evaluated the relationship between the polymorphisms of p53, p21, and MDM2, which plays a role in gene stability, and the arsenic-related RCC risk. Here, we found that p53 Pro/Pro genotype and MDM2 SNP309 GG genotype significantly increased RCC… CONTINUE READING

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