The polymorphisms in DC-SIGNR affect susceptibility to HIV type 1 infection.

  title={The polymorphisms in DC-SIGNR affect susceptibility to HIV type 1 infection.},
  author={Nuanjun Wichukchinda and Yoshihiro Kitamura and Archawin Rojanawiwat and Emi E. Nakayama and Haihan Song and Panita Pathipvanich and Wattana Auwanit and Pathom Sawanpanyalert and Aikichi Iwamoto and Tatsuo Shioda and Koya Ariyoshi},
  journal={AIDS research and human retroviruses},
  volume={23 5},
Dendritic cell-specific intercellular adhesion molecule-3 (ICAM-3) grabbing nonintegrin (DC-SIGN) and its homologue DC-SIGNR (DC-SIGN related) have been thought to play an important role in establishing HIV infection by enhancing trans-infection of CD4(+)T cells in the regional lymph nodes. To identify polymorphisms associated with HIV-exposed seronegative (ESN) individuals in Thais, genomic DNA from 102 HIV-seronegative individuals of HIV-seropositive spouses, 305 HIV-seropositive individuals… CONTINUE READING
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