The polymorphism rs3024505 proximal to IL-10 is associated with risk of ulcerative colitis and Crohns disease in a Danish case-control study

@inproceedings{Andersen2009ThePR,
  title={The polymorphism rs3024505 proximal to IL-10 is associated with risk of ulcerative colitis and Crohns disease in a Danish case-control study},
  author={Vibeke Andersen and Anja Ernst and Jane Christensen and Mette Christina {\O}stergaard and Bent Ascanius Jacobsen and Anne Tj{\o}nneland and Henrik B Krarup and Ulla Vogel},
  booktitle={BMC Medical Genetics},
  year={2009}
}
BackgroundCrohns disease (CD) and ulcerative colitis (UC) are characterized by a dysregulated inflammatory response to normal constituents of the intestinal flora in the genetically predisposed host. Heme oxygenase-1 (HO-1/HMOX1) is a powerful anti-inflammatory and anti-oxidant enzyme, whereas the pro-inflammatory interleukin 1β (IL-1β/IL1B) and anti-inflammatory interleukin 10 (IL-10/IL10) are key modulators for the initiation and maintenance of inflammation. We investigated whether single… CONTINUE READING
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