The polymorphism of GSTM1, mutagen sensitivity in colon cancer and healthy control.

@article{Guo1996ThePO,
  title={The polymorphism of GSTM1, mutagen sensitivity in colon cancer and healthy control.},
  author={Jian Ying Guo and Di-ling Wan and Rongping Zeng and Qing-xue Zhang},
  journal={Mutation research},
  year={1996},
  volume={372 1},
  pages={17-22}
}
The aim of this article is to study the relationship between GSTM1 polymorphism and colon cancer and to compare the chromosomal breakage induced by mutagen in a colon cancer group and healthy controls. Using PCR to identify the GSTM1 genotype, we found the frequency of GSTM1- in colon cancer (n = 19) and control group (n = 23) was 36.8% and 26.1%, respectively (p > 0.05, chi 2-test). The bleomycin-induced chromosomal breakage (break/cell) in the patient group was 0.75 +/- 0.29, and in the… CONTINUE READING