The polymorphism frequency spectrum of finitely many sites under selection.

@article{Desai2008ThePF,
  title={The polymorphism frequency spectrum of finitely many sites under selection.},
  author={Michael M Desai and Joshua B. Plotkin},
  journal={Genetics},
  year={2008},
  volume={180 4},
  pages={2175-91}
}
The distribution of genetic polymorphisms in a population contains information about evolutionary processes. The Poisson random field (PRF) model uses the polymorphism frequency spectrum to infer the mutation rate and the strength of directional selection. The PRF model relies on an infinite-sites approximation that is reasonable for most eukaryotic… CONTINUE READING