The polymorphism at position -174 of the IL-6 gene is not associated with inflammatory bowel disease.

@article{Klein2001ThePA,
  title={The polymorphism at position -174 of the IL-6 gene is not associated with inflammatory bowel disease.},
  author={William G. Klein and Andreas Tromm and Thomas Griga and H. J. Fricke and Christian Folwaczny and Michael Hocke and Klaus Dr Eitner and Martin B. Marx and Joerg T. Epplen},
  journal={European journal of gastroenterology & hepatology},
  year={2001},
  volume={13 1},
  pages={
          45-7
        }
}
  • William G. Klein, Andreas Tromm, +6 authors Joerg T. Epplen
  • Published in
    European journal of…
    2001
  • Medicine
  • OBJECTIVE Inflammatory bowel diseases (IBD) are multifactorial disorders, characterized by failure to limit the inflammatory response to luminal antigens. Genetic factors play an important role in the pathogenesis, but little is known about the accountable genes. Increased secretion of pro-inflammatory cytokines appears crucial in the initiation of the inflammatory response. METHODS To evaluate the role of the IL-6 gene in IBD, a functionally relevant polymorphism in the promoter region (G/C… CONTINUE READING

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