The polymorphism IL-1β T-31C is associated with a longer overall survival in patients with multiple myeloma undergoing auto-SCT

@article{Vangsted2009ThePI,
  title={The polymorphism IL-1β T-31C is associated with a longer overall survival in patients with multiple myeloma undergoing auto-SCT},
  author={Annette Juul Vangsted and Tobias W Klausen and Wojciech Ruminski and Peter Gimsing and Nils Frost Andersen and Anne Ortved Gang and Niels Abildgaard and Lene Meldgaard Knudsen and Johan Lanng Nielsen and Henrik Gregersen and Ulla Vogel},
  journal={Bone Marrow Transplantation},
  year={2009},
  volume={43},
  pages={539-545}
}
Proinflammatory cytokines are suspected to play a role in the pathogenesis of multiple myeloma (MM). Therefore, it is possible that inborn genetic variations leading to a modified expression of these cytokines will influence the outcome for these patients. We investigated 348 MM patients undergoing high-dose melphalan treatment followed by Auto-SCT and examined the influence of single nucleotide polymorphisms (SNPs) in genes involved in the inflammatory response. We found that the polymorphism… CONTINUE READING

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